Characterisation of group A streptococcal (GAS) isolates from children with tic disorders.

BACKGROUND & OBJECTIVES: An association between the onset or recrudescence of some neuropsychiatric disorders in children such as tic disorders and group A streptococcal (GAS) infections has been suggested. No information is available on the characterization of GAS strains associated with such disorders. The present study was undertaken to characterize the GAS strains isolated from children with tic disorders and to determine and correlate the antistreptolysin O (ASO) titre with the presence of GAS. METHODS: During 1996-2001, 368 children with tic disorders were investigated for possible exposition to streptococcal antigens. All children, at the time of the first visit and during the follow up visits were apparently healthy and showed no clinical evidence of streptococcal infections or post streptococcal sequelae. Blood and throat swab samples were collected and serological and bacteriological tests done. The isolates obtained were investigated for T pattern, M protein and emm type, as well as for the production of protease. RESULTS: Of the 800 throat swabs studied 100, corresponding to 67 patients, were positive for GAS; 49 children were found positive for GAS only once during the study, 18 had more than one sample positive for different serotypes, 8 were positive twice or more for the same type. ASO titres of these children were, in general, elevated. Five types, namely type M12, 3, 13, 11, 1, accounted for 39 per cent of the isolates, M12 being the most common, but a large number of different types were also found. A large number of isolates (62%) showed an elevated prodution of protease in the casein plate assay. INTERPRETATION & CONCLUSION: Despite the high level of ASO titres found, the results were not in favour of a particular virulence or invasivity of the isolates. Only a few colonies per sample were found indicating that factors different from the microbial virulence play a role in this type of disease.

Colour Doppler echocardiography in children with group A streptococcal infection related tic disorders.

BACKGROUND & OBJECTIVES: A possible relationship has been suggested between tic disorders and streptococcal infections. To understand the complex relationship between streptococcal infections and neuropsychiatric disorders in children the present study was done on colour Doppler echocardiography of patients with possible post-streptococcal tic disorders. METHODS: The patients were 23 children (22 males, 1 female) affected by tic disorders, who at the time of the observation presented (or had presented in the past) signs of streptococcal infections temporally related to the onset or recrudescence of tic disorders. Echocardiographic examination and laboratory tests were performed on these children. RESULTS: In 4 cases a mild mitral insufficiency and in 8 cases a minimal mitral insufficiency was seen, all haemodynamically not significant. Follow up studies (up to 1 yr) showed the consistency and persistence of these findings. Of the 12 patients with echocardiographic abnormalities, 10 displayed very high anti streptolysin O (ASO) titres, 5 showed positive cultures for GAS and 9 had abnormal ESR, even if no significant differences were found in respect to patients with tics and normal echocardiography. INTERPRETATION & CONCLUSION: With the caution due to the design of study and to low number of patients, our data seem to indicate that the pathophysiology of GAS-infection related tic disorders is similar to that SC, at least in some cases.

Effect of right atrial pacing, intravenous amiodarone and beta blockers for suppression of atrial fibrillation after coronary artery bypass surgery: a pilot study

OBJECTIVE: This pilot study aimed to compare right atrial pacing, intravenous amiodarone and oral beta-blockers in the prevention, time to onset, duration and effect on hospital stay of postoperative atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG) at our center. BACKGROUND: AF is the most common arrhythmic complication after CABG and is related to increased morbidity, length of hospital stay and costs. Trials with different drugs and other therapeutic modalities including beta-blockers, intravenous amiodarone and override suppression of automatic atrial foci by atrial pacing have shown partial success as preventive measures. However, a comparison between those three interventions has not been reported. METHODS: Thirty-six consecutive patients that underwent CABG at our institution were randomly assigned to atrial pacing (18 patients) and intravenous amiodarone (18 patients) after baseline clinical, electrocardiographic and hemodynamic assessment. All patients received concomitant oral metoprolol or atenolol right after extubation. Thirty-three patients who had CABG at our center in the previous two months and that only received beta-blockers during their perioperative period served as a control group. RESULTS: The majority of baseline clinical and hemodynamic characteristics were similar in all groups. Only one patient (5.6 per cent) developed AF in the atrial pacing group versus five (27.8 per cent) on amiodarone and six (18.2 per cent) who only received beta-blockers. That finding, however, did not attain statistical significance (p > 0.05). After adjusting for potential confounders, the odds of occurrence of AF was 77 per cent lower in atrial pacing patients (OR = 0.23; 95 per cent CI: 0.02, 2.20; p = 0.09) and 2.36 times higher in those on amiodarone (95 per cent CI: 0.55, 10.24; P = 0.053) when compared to patients which only received beta blockers. Since only one patient on right atrial pacing developed atrial fibrillation, the analysis of the median time to onset and median duration of atrial fibrillation was restricted to those assigned to amiodarone and those who only received beta-blockers showing no statistically significant differences (p > 0.05)...

Influencia de la administración de información preoperatoria sobre los niveles de ansiedad en pacientes adultos sometidos a cirugía de terceros molares / Influence of pre-operative information in decreasing anxiety of adults submitted to surgical procedures

La influencia de la información preoperatoria, ha sido encontrada útil en la disminución del nivel de ansiedad de estado, ó condición emocional transitoria del organismo humano inducido por el procedimiento quirúrgico. En el presente estudio se comparó el dar o no información prequirúrgica a un grupo de 50 sujetos siendo asignados aleatoriamente, 25 al grupo control (sin información) y 25 al grupo estudio. Primero se les suministró un cuestionario de pregunta abierta semiestructurada para indagar en el sentido común del paciente su concepto sobre la cirugía, antecedentes, experiencias, inquietudes y temores. Luego se administró la información y el día de la cirugía se ofreció un ejemplar de dos cuestionarios de autoevaluación correspondientes a la prueba de STAL para evaluar la Ansiedad Estado y la Rasgo. El grupo control presentó mayor nivel de Ansiedad Estado que el grupo estudio, siendo esta diferencia estadísticamente significativa (p=0.0002). Se necesita más investigación para determinar la importancia clínica de la preparación prequirúrgica de los pacientes. Los pacientes sin experiencias previas mostraron mayores niveles de Ansiedad Estado y Rasgo que los que tenían experiencias; y los pacientes con experiencias previas negativas presentaron igualmente mayores niveles de Ansiedad Estado y Rasgo con respecto a los de experiencias positivas, aunque ninguna de las dos diferencias fue estadísticamente significante.